BIOL518Readings

Readings for BIOL518

8/22 Robert Koch’s 1884 paper The Etiology of Tuberculosis (Koch’s postulates)
8/24 Emerging Infections: An Evolutionary Perspective
8/29 Tan’s 1999 PNAS paper
9/7 Mecsas & Strauss, on Type 3 Secretion Systems & PAIs
9/12 Hacker & Carniel, on pathogen evolution
9/19-21 Falkow on introduction to in vivo methods
Remember, your group will do ONE of the following methods:
     IVET: Heithoff
     DFI: Valdivia & Falkow Science 277:2007 article
     STM: Science 269:400
     SCOTS: Studying Mycobacterium tuberculosis virulence
     RIVET: Studying Vibrio cholerae virulence

11/16 Falkow: Who speaks for the microbes?

11/30 Introductory article to bacterial genomics: Schwartz EID and Fraser EID article
12/5 Weinstock EID article, Fleischmann article
12/7 Cummings EID article, Dobrindt J. Bact. Article

Web links for bioinformatics section
NCBI homepage: http://www.ncbi.nlm.nih.gov
TIGR (www.tigr.org)
Sanger Centre (http://www.sanger.ac.uk/Projects/Microbes/).
A BLAST help page: http://www.ncbi.nlm.nih.gov/Education/BLASTinfo/information3.html

Genome Glossary, from the OakRidge National Labs Human Genome Project site: http://www.ornl.gov/sci/techresources/Human_Genome/glossary/index.shtml

Organized list of links to sequenced genomes of bacteria, fungi, etc.: http://www.ornl.gov/sci/techresources/Human_Genome/vl_organisms.shtml

Pfam, for checking on protein motifs: http://pfam.wustl.edu/

Additional very useful & interesting readings
Super review on PAI’s by Hacker & Kaper
Achtman 1999 PNAS: evolutionary relationships among pathogenic yersiniae